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Magnetofection Magnetic Transfection

VM40000 - ViroMag Viral Gene Delivery Reagent

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ViroMag Transduction Reagent is a magnetic nanoparticles formulation designed to increase virus infection and transduction capacities. It is suitable for all viruses. Based on the Magnetofection technology, this reagent allows concentration of the complete applied dose of viral particles onto cells within minutes, inducing a significant improvement of virus transduction with extremely low vector doses. Due to its specific properties, ViroMag is ideal for infecting non-permissive cells. No molecular biology processes or biochemical modifications are required. This reagent must be used with a magnetic plate.


Figure 1: Protocol. In the process of Magnetofection, nucleic acids, transfection reagents or viruses are associated with specific magnetic nanoparticles. The resulting molecular complexes are then concentrated and transported into cells supported by an appropriate magnetic field. 

Figure 2: ViroMag enhances adenoviral infection. K562, PBL and NIH-3T3 cells were infected with an adenovirus alone (Ad-LacZ) or with complexes of adenovirus and 3 μl of ViroMag. Cells were submitted or not to magnetic field and beta-Galactosidase expression was determined 24H after infection.

Figure 3: Time Course of HIV Infection with or without ViroMag.

Features

  • Increases transduction efficiency
  • Accelerates the transduction process
  • Efficient for hard-to-infect and non-permissive cells
  • Concentrates viral dose onto the cells
  • Suitable for all types of viruses and mammalian cells
  • Synchronizes cells adsorption/infection without requiring modifications of the viruses

Applications

  • Increasing viral transduction efficiency without Polybrene
  • Cell transduction with all viral vectors

Sizes

  • VM40100 – ViroMag Transduction Reagent, 100 µl (30-500 transductions)
  • VM40200 – ViroMag Transduction Reagent, 200 µl (60-1000 transductions)
  • VM41000 – ViroMag Transduction Reagent, 1ml (300-5000 transductions)

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