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Phage Display

PSKAN2 - pSKAN Phagemid Display System, anti-SPINK1 (hPSTI) antibody

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The monoclonal mouse IgG (Clone R XXIII) is an antibody to human pancreatic trypsin inhibitor domain (hPSTI). It recognizes soluble hPSTI as well as hPSTI in the pSKAN phagemid pIII-hPSTI fusion protein.  The PSKAN2 was developed specifically for our PSKAN Phagemid Display System, but can also be used in other applications related to the human pancreatic secretory trypsin inhibitor (hPSTI)

Note on anti-hPST1 antibody (SPINK1):
  • "About 10 percent of prostate cancer patients are SPINK1-positive and strategies to block SPINK1 signaling may have utility in this subset of patients. These studies should stimulate the development of antibody-based therapies against SPINK1 or targeting of EGFR in SPINK1-positive cancer patients," says study author Bushra Ateeq, a research fellow at the U-M Medical School.

PAGE of pSKAN phages presenting different hPSTI-pIII fusion proteins followed by Western blot with anti-pIII (Lane 1-5); M13K07 wild type phage as control (Lane M13). Two bands are visible with pSKAN phages: one for pIII and one for the larger hybrid protein hPSTI-pIII. In M13 wild type phages only one band is detected resulting from pIII.

Features

  • Antibody to Serine protease Kazal-type 1 (SPINK1; human pancreatic secretory trypsin inhibitor domain (hPSTI))
  • Recognizes native hPSTI (soluble as well as hPSTI in the pSKAN phagemid pIII-hPSTI fusion protein)
  • Monoclonal mouse IgG (clone R XXIII)
  • Reports indicate a potential of SPINK1 as an extracellular therapeutic target in prostrate cancer)

Applications

  • For use with our PSKAN Phagemid Display System
  • Applications related to the human pancreatic secretory trypsin inhibitor (hPSTI)

Contents

  • Anti-SPINK1 (hPSTI) antibody, monoclonal mouse, 100µl

Literature