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Magnetic Silica Beads for Proteomics

Magnetic Silica Beads for Proteomics

We offer several formats of magnetic silica beads specifically for applications in proteomics.
 
Magnetic silica beads with a hydrophobic surface are well suited for protein and peptide sample concentration, desalting and fractionation, and reducing sample complexity. The surface is coated with C4, C8 or C18 -alkyl groups that bind to the protein/peptide hydrophobic interactions. Each surface is suited for specific purposes:
 
  • C4 groups - capture, concentration and purification of proteins from general protein mixtures, cell lysates, and culture supernatant; relatively low hydrophobicity
 
  • C8 groups - capture and purification of peptides and proteins from clinical samples of urine, saliva and CSF; intermediate hydrophobicity
 
  • C18 groups - desalting of peptides or protein tryptic digest prior to mass spectrometry, concentration of peptides, and the capture and purification of peptides and proteins from serum and plasma; high hydrophobicity

 

Magnetic silica beads coated with a weak cation exchange surface and weak anion exchange surface are ideal for reduction of protein or peptide complexity. Applications include sample preparation and prefractionation prior to mass spectrometry or SDS-PAGE analysis, biomarker analysis and serum/plasma profiling. These beads are counters to one another and it is recommended that the user test both types to determine which is the best fit for the application.

 

See Also: Magnetic Silica Beads coated with Protein A or Protein G

 

If the product you are looking for is not listed, please contact us.