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Magnetofection Magnetic Transfection

AM70000 - AdenoMag Viral Gene Delivery Reagent (Adenovirus & Adeno Associated Virus)

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AdenoMag Viral Gene Delivery Reagent is a magnetic nanoparticles formulation specifically designed to enhance Adenovirus and Adeno Associated Virus (AAV) infection and transduction capacities. Based on the Magnetofection technology, it allows concentration of the complete applied dose of viral particles onto cells within minutes, inducing a significant improvement of virus infectivity with extremely low vector doses. Due to its specific properties, AdenoMag is applicable to all adenoviral and AAV vectors and is ideal for infecting non-permissive cells. This reagent demonstrates an exceptionally high efficiency in promoting, controlling and assisting Adenoviral and AAV transductions. AdenoMag must be used with a magnetic plate.



Figure 1: AdenoMag enhances the number of infected cells: Representative images of HUVEC infected with Ad-GFP (MOI of 5) and either 0 (d), 0.5 (e) or 1 μl (f) of AdenoMag. Photos were taken under white field (a, b and c) and fluorescence (d, e and f) after 48 H infection.

Figure 2: Adenomag enhances transgene expression: beta-Galactosidase expression was determined in HEK-293, NIH-3T3, C6 and COS7 cell lines after 24H of infection with Ad-LacZ, Ad-LacZ with Polybrene (Ad-LacZ + Pb) or Ad-LacZ with 2 μL of AdenoMag (Ad-LacZ + AM).

Features

  • Increases transduction efficiency
  • Accelerates the transduction process
  • Efficient for hard-to-infect and non-permissive cells
  • Concentrates the viral dose onto the cells
  • Synchronizes cells adsorption/infection without modifications of the viruses
  • Suitable for all mammalian cells

Applications

  • Adenovirus and adeno-associated-virus transduction in vitro

Sizes

  • AM70100 - AdenoMag Transfection Reagent, 100 µl (500-1,000 transductions)
  • AM70200 - AdenoMag Transfection Reagent, 200 µl (1,000-2,000 transductions)
  • AM71000 - AdenoMag Transfection Reagent, 1ml (5,000-10,000 transductions)