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Live Cell Imaging of Nuclear Proteins

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Live Cell Imaging of Nuclear Proteins

Features:
  • Large selection of genes
  • Sequence-documented vectors
  • EGFP fusion protein expression (N- or C- terminal tag)
  • Experimentally approved
Mitosis is the process by which a eukaryotic cell separates the chromosomes in its cell nucleus into two identical sets in two nuclei. Failure to divide properly usually results in the death of both new and old cell. Many different proteins take part in this complex process, and the investigation of it is of utmost importance to life science and medical research. A pivotal point for a better understanding of mitosis and the significance of involved proteins is Live Cell Imaging and the availability of adequate tools. 

MoBiTec now offers a large number of unique expression vectors coding for human proteins in fusion with EGFP. Most of hte fusion proteins can be expressed either with N- or C-terminal EGFP tag.
  • Kinetochore
  • Chaperone
  • Histone
  • Mitotic Checkpoint
  • Mis12 Complex, and
  • Hec1 Complex
Applications:
The kinetochore EGFP fusion proteins can be used in modern fluorescence microscopy techniques to determine
  • localization
  • binding
  • dynamics, and, when a second color is available,
  • protein-protein interactions and
  • protein-protein proximities
by applying fluorescence methods like FRET, FRAP, FCS, RICS, FCCS, and F3H.