Magnetofection utilizes a magnetic field to promote transfection. The nucleic acid to be transfected is complexed to magnetic nanoparticles; the complexes are then added to a culture vessel containing the target cells. The culture vessel is placed on a Magnetofection Magnet and the complexes are then attracted to the cell membrane and subsequently into the cells.
Magnetofection has been successfully applied to a wide range of primary cells and cell lines. Various Magnetofection reagents have been optimized for plasmid vectors, viral vectors, and siRNA.
Specialized Magnetofection reagents have been developed for adenoviruses, retroviruses, and lentiviruses. Transfection of neurons can be accomplished with NeuroMag, which is is specifically designed for that purpose. And CombiMag has been designed to be used in combination with standard transfection reagents in order to enhance transfection efficiency.