The latest innovation based on Magnetofection™ technology, SilenceMag is the most efficient siRNA delivery system available. Simple, rapid and easy to use, SilenceMag is serum compatible and non toxic. Specifically designed for siRNA delivery, SilenceMag allows studying gene silencing at very low doses of siRNA. SilenceMag formulation gives reliable high gene silencing efficiencies in numerous cell types (primary cells, hard to transfect & cell lines) and is suitable for all siRNA applications (co-transfection & endogenous gene silencing).

Highly efficient
SilenceMag concentrates and introduces large quantities of siRNA duplexes into cells leading to exceptional knockdown effects, even with very low doses of siRNA.

Mix, incubate & test
SilenceMag is an easy and ready-to-use reagent:

Mix siRNA and SilenceMag
Add these complexes to cells
Incubate culture plate on magnetic plate for 15 minutes
Remove magnetic plate and process as usual

List of Cells Tested

Download SilenceMag User Manual

See our Magnetofection FAQ

What is Magnetofection?

This method associates DNA with magnetic nanoparticles coated with cationic molecules. The resulting molecular complexes are then transported into cells supported by an appropriate magnetic field. Magnetofection exploits magnetic force exerted upon gene vectors towards, possibly even into, the target cells. In this manner, the complete applied vector dose gets concentrated on the cells within a few minutes so that 100% of the cells get in contact with a significant vector dose. Inspired by the validated and recognized magnetic drug targeting technology, this innovative method is a revolution for transfection and infection.

magnetofection

MAGNETOFECTION™

Examples

High gene silencing efficiency

eff

graph

Use 10 to 100 times less siRNA

Universal
SilenceMag is convenient for all siRNA applications: co-transfection & endogenous applications.

Endogenous

endo

Co-transfection

Ordering information
200μl of SilenceMag reagent is sufficient for 200 transfections on a 24 well plate and for 400 transfections on a 96 well plate.
NOTE: As for all Magnetofection reagents, SilenceMag requires an appropriate magnetic field. Two magnetic plates especially designed for Magnetofection are provided to exert this specific magnetic field. The special geometry of one magnetic plate produces a strong magnetic field that is suitable for 96-well plates ( cat. # MF10096) and the other one (cat. # MF-10000) is suitable for all culture dishes.