Magnetofection is our term for Magnetic Transfection. Magnetofection associates nucleic acids or other vectors with magnetic nanoparticles coated with cationic molecules. The magnetic nanoparticles are complexed with vectors (DNA, siRNA, oligos, virus, etc.) by salt-induced colloidal aggregation and electrostatic interaction. The resulting molecular complexes are then attracted to target cells by an appropriate magnetic field (Magnetofection Magnet), and enter the cells by endocytosis. In this manner, the complete applied vector dose gets concentrated on the cells within a few minutes. As a result, 100% of the cells come into contact with a significant vector dose.
Special Magnetofection reagents have been developed for many applications. These include PolyMag (for general use); CombiMag (for use in combination with standard lipid based transfection reagents); ViroMag and ViroMag R/L (to increase transduction efficiency of viral vectors); NeuroMag (specialized for use with neurons); and SilenceMag (siRNA delivery).
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