Antibody & Protein Delivery

Ab-DeliverIN^TM is the first dedicated intracellular antibody delivery reagent. This lipid formulation is the first serum compatible reagent allowing the delivery of functional antibodies into living cell.

Due to its unique properties, Ab-DeliverIN^TM forms non-covalent complexes with antibodies through electrostatic and hydrophobic interactions. Consequently, chemical or genetic couplings are not necessary.

Ab-DeliverIN^TM opens up new fields of investigation in proteomics to elucidate complex molecular mechanisms or to design potential new therapies. For example, the intracellular delivery of blocking antibodies could inhibit and/or neutralize protein function.

FEATURES

• Functionally active antibody delivery
• Highly efficient in both primary cells and cell lines
• Serum compatible
• Biodegradable and non-cytotoxic
• Simple protocol
• Ready-to-use

Intracellular localization of functional antibody

Ab-DeliverIN^TM delivered antibodies retain their structure and function. This exclusive feature allows the antibody to reach and bind to its intracellular target. For example, intracellular staining or protein function blocking can now be achieved.

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Highly efficient antibody transfection

With Ab-DeliverIN^TM you can achieve a large number of positive cells containing the desired antibody.

In comparison with other protein delivery systems, Ab-DeliverIN^TM demonstrates higher delivery efficiency inside living cells.

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Large range of cells tested

Ab-DeliverIN has been successfully tested with a range of immortalized and primary cells, including primary neurons and glial cells.

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Serum compatible

Ab-DeliverIN is compatible with culture media with or without serum.

Fast Delivery

In vitro and in vivo experiments can be accomplished quickly and directly. High efficiencies can be achieved in less than 5 hours.

Biodegradable and non-toxic

Ab-DeliverIN is fully biodegradable and does not interfere with cellular mechanisms. Because of its specific formulation, Ab-deliverIN is quickly degraded in cells, maintaining high cell viability in each experiment.

Ready-to-use with a simple 3-step protocol

1. Mix Ab-DeliverIN and antibody
2. Incubate 10 minutes at room temperature
3. Add to cells and incubate under standard conditions

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